Broccoli Sprout Extract by LLS | Contains Activated Sulforaphane | 60 Capsules | 18,000mg of Whole Plant Equivalent per Serving | Sulforaphane Supplement | Potent Antioxidant Content

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The salary of LB is supported by a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). EC is supported by an Australian Government Research Training Program Scholarship at Edith Cowan University. WM is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship. The salary of MS is supported by a Royal Perth Hospital Research Foundation Career Advancement Fellowship (ID: 00/2020). GB is supported by the Big C Scientific/Clinical Research Grant 11-13R. The salary of JL is supported by a National Heart Foundation of Australia Future Leader Fellowship (ID: 102817). The salary of JH is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (Grant number 1116973). Conflict of Interest It is an extract and the ratio is 15:1 so 7500mg of raw broccoli was used to make the amount of extract in one capsule. Broccoli can benefit your heart health by lowering levels of “bad” (LDL) cholesterol. It can help even those genetically prone to high cholesterol regulate their cholesterol levels (x). Anti-Inflammatory Research has shown that some types of vegetables may have greater health benefits than others for certain health conditions, such as diabetes, cardiovascular disease, and cancer ( Cooper et al., 2012; Aune et al., 2017). This may be due to the presence of unique bioactive phytochemicals with potent health-related effects. Therefore, targeted recommendations surrounding the intake of specific types of vegetables with protective health benefits could assist in the reduction of non-communicable diseases.

If you don't notice anything, it doesn't mean the ingredients aren't working. Everything we ingest has an effect thatWooltorton E. Facts on mercury and fish consumption. CMAJ. 2002 Oct 15;167(8):897. PMID: 12406950; PMCID: PMC128404. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-489. doi:10.1007/s10637-014-0189-z Several human intervention trials have also been performed. In a 4-week parallel, randomized, double-blind placebo-controlled study including 81 human participants with type 2 diabetes, 10g/day broccoli sprout powder (225μmol sulforaphane daily) decreased fasting serum insulin and insulin resistance by 18.2 and 14.2%, respectively ( Bahadoran et al., 2012). Positive results were also seen in a randomized double-blind placebo-controlled study including 97 Scandinavian patients with type 2 diabetes. In this study, patients consumed broccoli sprout extract (150μmol sulforaphane/day) or a placebo over a 12-week period. The glucoraphanin-rich broccoli sprout extract improved both fasting glucose and HbA1c (7.38–7.04%) in obese patients with dysregulated diabetes (BMI >30kg/m 2; HbA1c > 50mmol/mol) ( Axelsson et al., 2017). The authors noted that this reduction in HbA1c was likely to reflect a clinically meaningful effect, as an HbA1c of 7% is the treatment goal of the American Diabetes Association ( Axelsson et al., 2017). In a recent 12-week randomized controlled parallel intervention trial, 92 patients with type 2 diabetes were randomized to one of three different diets: 500g/day bitter and strong-tasting root vegetables and cabbages, 500g/day mild and sweet-tasting root vegetables and cabbages, or 120g/day mild and sweet-tasting root vegetables and cabbages (normal diet) ( Thorup et al., 2021). Improvements in glycemic control were noted in both groups with increased vegetable intake; however, consumption of bitter and strong-tasting vegetables (including kale and cabbage) had the greatest improvements to fasting glucose (4-fold), total cholesterol (2-fold), and body fat mass (2-fold) ( Thorup et al., 2021). Hypertension You should not take food supplements as a substitute for a varied balanced diet or a healthy lifestyle. Mild side effects have been associated with sulforaphane supplements, such as an increase in gas, constipation, and diarrhea ( 17, 29).

Previous cell-based and human studies have indicated that sulforaphane exposure is associated with decreased breast cancer progression, including initiating cell cycle arrest and apoptosis ( Kuran et al., 2020). Sulforaphane treatment led to the inhibition of cell proliferation of breast cancer cells lines, MCF-7 and MDA-MB-231 and provoked cytotoxic activity by changing cysteine residues of the promyelocytic leukemia protein, known to promote proliferation of the MCF-7 breast cancer cell line ( Alhazmi et al., 2020). Sulforaphane has also been shown to modify cell migration and expression of epithelial mesenchymal transition markers that play a large role in breast cancer metastasis ( Bagheri et al., 2020). We felt the Phytofare® Catechin Complex was such a potent ingredient with ultra high bioavailability, it would further enhance our product. Test results showed that Phytofare® delivered 10x higher levels of active phyto-nutrients into the blood. Delivers complete phyto-complexes. All eight green tea catechins were detected in the blood as opposed to just one or two as is present in generic extracts. Greatly prolongs the presence of the phyto-complexes in the blood. With most extracts, all traces are eliminated from the blood in just a few hours. With Phytofare® all eight catechins remained in in the blood at therapeutic levels after 24 hours, making it effective in “once a day” applications. Klomparens EA, Ding Y. The neuroprotective mechanisms and effects of sulforaphane. Brain Circ. 2019;5(2):74-83. doi:10.4103/bc.bc_7_19 Sulforaphane has been indicated to have multiple roles in a variety of key metabolic pathways involved in prostate cancer development including inhibition of angiogenesis and cell proliferation and initiating apoptosis ( Traka et al., 2014; Soundararajan and Kim, 2018; Livingstone et al., 2019). Treatment with sulforaphane significantly reduced expression of key glycolytic genes, including hexokinase II and pyruvate kinase M2, in prostate cancer cell lines, LNCaP, 22RV1, and PC-3, and in transgenic mouse models, TRAMP and Hi-Myc ( Singh et al., 2019). Sulforaphane also induced S-phase and G2/M-phase cell cycle arrest, enhanced histone acetylation, and up-regulated cell cycle proteins in the prostate cancer cell lines, DU145 and PC-3 ( Rutz et al., 2020), suggesting that sulforaphane treatment leads to reduced cell proliferation activity. Despite these promising findings, more research is needed to determine whether sulforaphane could improve heart health in humans. May Have Antidiabetic EffectsKubo, E., Chhunchha, B., Singh, P. et al.Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. Sci Rep 7, 14130 (2017). https://doi.org/10.1038/s41598-017-14520-8 Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol. 2014 Jun;7(2):60-72. doi: 10.2478/intox-2014-0009. Epub 2014 Nov 15. PMID: 26109881; PMCID: PMC4427717. There have been numerous human studies investigating the influence of sulforaphane on prostate cancer. Traka and coworkers evaluated the effect of a once-a-week consumption of broccoli soups with increasing concentration of glucoraphanin in a prostate cancer cohort on active surveillance. They indicated a dose-dependent suppression in gene expression and pathways associated with the development and progression of prostate cancer ( Traka et al., 2019). Consistent with this study, Zhang and coworkers assessed the influence of daily consumption of either 200µmol broccoli sprout extract or placebo in men scheduled for prostate biopsy and demonstrated changes in gene expression with the downregulation of genes associated with prostate cancer progression ( AMACR and ARLNC1) ( Zhang et al., 2020). Breast Cancer These supplements are typically made from broccoli or broccoli sprout extract and generally concentrated, containing more sulforaphane than what’s naturally found in food.

Sulforaphane can be obtained naturally from a range of cruciferous vegetables. These vegetables not only provide sulforaphane but also many other important vitamins, minerals, and antioxidants.The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher’s Note We are not aware of any intolerances, but we cannot rule out individual intolerances. Please adhere to our Broccoli extract can improve digestion and intestinal health. Broccoli forms a compound called indolocarbazole (ICZ) when the body breaks it down during digestion. ICZ binds to specific receptors in the intestines that help regulate the probiotic flora necessary to absorb nutrients from food. It also helps to keep the walls of the intestine strong, preventing undigested food from leaking into the bloodstream (x).